Professor Fraydoon Rastinejad

Qualifications

BA in Mathematics and Biochemistry & Molecular Biology (Northwestern University, Evanston, IL)
PhD in Biophysics (University of Pennsylvania, Philadelphia, PA)

Academic Positions

Professor of Biochemistry and Structural Biology at the Nuffield Department of Medicine and Target Discovery Institute, University of Oxford.
Nicholas Kurti Senior Research Fellow, Brasenose College, Oxford.

Academic Background and Previous Positions

1993-1995 Postdoctoral fellow, Yale University, New Haven, CT
1995-2001 Assistant Professor of Pharmacology, University of Virginia School of Medicine
2001-2007 Associate Professor of Pharmacology and Biochemistry & Molecular Genetics, University of Virginia School of Medicine
2007-2010 Professor of Pharmacology and Biochemistry & Molecular Genetics, University of Virginia School of Medicine
2010-201 Professor, Sanford Burnham Preby Medical Discovery Institute
2018- Wellcome Trust Senior Investigator, University of Oxford
2019- Professor of Biochemistry and Structural biology, University of Oxford

Research Interests

Gene-Regulation, Transcription Factors, Nuclear Receptors, Biochemistry, Structural biology, Chemical Biology.

Publications

Li W, Hang S, Fang Y, Bae S, Zhang Y, Zhang M, Wang G, McCurry MD, Bae M, Paik D, Franzosa EA, Rastinejad F, Huttenhower C, Yao L, Devlin AS, Huh JR. A bacterial bile acid metabolite modulates Treg activity through the nuclear hormone receptor NR4A1. Cell Host Microbe. 2021 Sep 8;29(9):1366-1377.e9.

Cheng X, Prange-Barczynska M, Fielding JW, Zhang M, Burrell AL, Lima JD, Eckardt L, Argles I, Pugh CW, Buckler KJ, Robbins PA, Hodson EJ, Bruick RK, Collinson LM, Rastinejad F, Bishop T, Ratcliffe PJ. Marked and rapid effects of pharmacological HIF-2α antagonism on hypoxic ventilatory control. J Clin Invest. 2020 May 1;130(5):2237-2251.

Hang S, Paik D, Yao L, Kim E, Trinath J, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, Zheng Y, Longman RS, Rastinejad F, Devlin AS, Krout MR, Fischbach MA, Littman DR, Huh JR. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.

Wu D, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim Y, Khorasanizadeh S, Rastinejad F. Bidirectional modulation of HIF-2 activity through chemical ligands. Nat Chem Biol. 2019 Apr;15(4):367-376.

Chandra V, Wu D, Li S, Potluri N, Kim Y, Rastinejad F. The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission. Nat Commun. 2017 Oct 11;8(1):868.

Wu D, Su X, Potluri N, Kim Y, Rastinejad F. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife. 2016 Oct 26;5:e18790.

Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors. Nature. 2015 Aug 20;524(7565):303-8.

Chandra V, Huang P, Potluri N, Wu D, Kim Y, Rastinejad F. Multidomain integration in the structure of the HNF-4α nuclear receptor complex. Nature. 2013 Mar 21;495(7441):394-8.

Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP, Rastinejad F. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature. 2008 Nov 20;456(7220):350-6.

Email

[email protected]

Links

https://www.ndm.ox.ac.uk/team/fraydoon-rastinejad