People

Gibbs-Seymour

Positions

Lecturer, Brasenose College
Marie Skłodowska-Curie Fellow, Sir William Dunn School of Pathology

Qualifications

PhD (Durham)

Academic Background and Previous Positions

Upon completing my doctoral studies in Durham, I joined the group of Niels Mailand based in the Center for Protein Research, University Copenhagen. After three years, I returned to the UK where I am currently working with Ivan Ahel in the Sir William Dunn School of Pathology. Through these positions I have been able to pursue my interest in how post-translational modifications regulate the cellular DNA damage response. 

Undergraduate Teaching Areas

Molecular cell biology and biochemistry

Research Interests

The integrity of cellular DNA is constantly challenged by endogenous and exogenous sources of damaging agents that cause genome instability, which is a common hallmark of many different cancer types. To protect the genome from damage, organisms have evolved a cellular defence mechanism termed the DNA damage response (DDR). The DDR includes a diverse set of signal transduction pathways and effector proteins that act to sense DNA lesions and effectively repair the damage, to limit propagation of genomic instability to daughter cells. The complex interplay within DDR pathways requires fine spatiotemporal regulation, which is in part achieved through post-translational modifications (PTMs), such as (ADP-ribosyl)ation, ubiquitylation, SUMOylation, phosphorylation, and acetylation. My research aims to understand how these signalling mechanisms are regulated within the DDR, and how they function to ensure genome stability and prevent tumourigenesis.

Publications

Gibbs-Seymour I, Fontana P, Rack J, Ahel I. (2016) HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 activity. Molecular Cell.

Gibbs-Seymour I, Oka Y, Rajendra E, Weinert B, Passmore L, Patel K J, Olsen J V, Choudary C, Bekker-Jensen S, Mailand N. (2015) Ubiquitin-SUMO circuitry controls activated Fanconi Anemia ID complex dosage at sites of DNA damage. Molecular Cell.

Mailand N, Gibbs-Seymour I, Bekker-Jensen S. (2013) Regulation of PCNA-protein interactions for genome stability. Nature Reviews Molecular Cell Biology.

Mosbech A, Gibbs-Seymour I, Kagias K, Thorslund T, Beli P, Povlsen L, Nielsen SV, Sedgwick G, Lukas C, Hartmann-Petersen R, Lukas J, Choudhary C, Pocock R, Bekker-Jensen S, Mailand N. (2012) DVC1/C1orf124 is a DNA damage-targeting VCP/p97 adaptor that promotes ubiquitin dependent responses to replication blocks. Nature Structural and Molecular Biology.

E-mail

[email protected]

Links

http://www.path.ox.ac.uk/