lythgoe k


Tutorial Fellow in Biology

Associated Professor (Dept of Biology)

Group Leader (Big Data Institute, Oxford)

Investigator (Pandemic Sciences Institute, Oxford)




BA (Oxford)

MSc (Imperial)

PhD (Edinburgh)

Academic Background

I did my PhD in population genetics at the University of Edinburgh before travelling to University of California, San Diego for a Research Fellowship where I spent two years at the lab bench working on the coevolution of bacteria and viruses (phage) that infect them. Following this I completed an MSc in Science Communication before becoming the Editor of Trends in Ecology & Evolution for seven years. Since then, I have held a series of Research Fellowships based first at Imperial College London, and more recently at the University of Oxford in both the Department of Biology and the Big Data Institute. I work on the epidemiology and evolution of viruses, including HIV, Hepatitis B virus, and Hepatitis C virus. More recently I have also worked on SARS-CoV-2 as the genetic lead of the ONS Covid Infection Survey.

Research Interests

The evolution and epidemiology of viruses


Undergraduate: Evolutionary Biology, Epidemiology and Infectious Disease. Graduate: Molecular Evolution of Viruses.


Ghafari et al. 2023. High number of SARS-CoV-2 persistent infections uncovered through genetic analysis of samples from a large community-based surveillance study. medRxiv 2023.01. 29.23285160

Lythgoe & Hall et al. 2021. SARS-CoV-2 within-host diversity and transmission. Science 372:6539

Lythgoe et al. 2021. Estimating hepatitis B virus cccDNA persistence in chronic infection. Virus Evolution 7:veaa063

Raghwani et al. 2018. Evolution of HIV-1 within untreated individuals and at the population scale in Uganda. PLoS Pathogens 14(7):e1007167

Lythgoe et al. 2017. Short-sighted viruses and a germline hypothesis for chronic viral infections. Trends in Microbiology 25(5):336

Fraser et al. 2014. Virulence and pathogenesis of HIV-1 infection: an evolutionary perspective. Science 343:1243727

Email [email protected]


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