Professor Jeremy Robertson
Professor of Chemistry and Tutorial Fellow in Organic Chemistry
MA, DPhil (both from Oxford)
Undergraduate in Chemistry at Oxford (1983-1987)
DPhil in Organic Chemistry supervised by Professor Sir J E Baldwin (1987-1990)
Post doctoral research at Columbia University, New York, supervised by Professor Gilbert Stork (1990-1992)
University Lecturer and Tutorial Fellow in Organic Chemistry, Oxford (1992 to date)
I cover all aspects of the Organic Chemistry component of Oxford's four year MChem degree
Natural product synthesis and synthetic methodology
Our group carries out research into the chemical synthesis of certain natural products selected because they present unique problems that we think we can solve in unusual and efficient ways. Our goals are to discover new chemistry and to gain deeper insights into reactivity and mechanism. We choose targets with interesting and potentially useful biological activity in part so that we can provide access to non-natural analogues that may be more selective or less toxic. Much of our research is inspired by considerations of how to assemble natural product structures and we also try to develop initially purely mechanistic hypotheses into synthetically useful processes.
1) Y Zhang, Z Xiong, Y Li, M Wilson, K E Christensen, E Jacques, P Hernández-Lladó, J Robertson, L L Wong, Nat. Synth. 2022, 1, (DOI: 10.1038/s44160-022-00166-6)
Enantioselective Oxidation of Unactivated C–H Bonds in Cyclic Amines by Iterative Docking-Guided Mutagenesis of P450BM3 (CYP102A1)
2) V A Palchykov, P C Dale, J Robertson, New J. Chem. 2021, 45, 9020
Nucleophilic Vinylic Substitution in Bicyclic Methyleneaziridines: SNVpi or SNVsigma?
3) W J M Lewis, D M Shaw, J Robertson, Beilstein J. Org. Chem. 2021, 17, 334
Synthesis of Legonmycins A and B, C(7a)-Hydroxylated Bacterial Pyrrolizidines
4) L A Harwood, L L Wong, J Robertson, Angew. Chem. Int. Ed. 2021, 60, 4434
Enzymatic Kinetic Resolution by Addition of Oxygen
5) K Y Seah, J Robertson, Tetrahedron Lett. 2020, 61, 152170
Enantioselective Synthesis of C(9) Hydroxy Analogues of Hederacines A and B
6) K Y Seah, J Robertson, Tetrahedron 2019, 75, 130661
Investigation of an Annulation-Fragmentation-Spirocyclisation Approach to Fawcettimine-type Lycopodium Alkaloids
7) J T R Liddon, P J Lindsay-Scott, J Robertson, J. Org. Chem. 2019, 84, 13790
Secondary Products from Intramolecular Cycloadditions of Azidoalkyl Enol Ethers and Azidoalkyl Vinyl Bromides. 1-Azadienes, their Reactions with Diphenylketene, and Radical Cyclizations to form Bi- and Tricyclic Lactams
8) L-D Syntrivanis, L L Wong, J Robertson, Eur. J. Org. Chem. 2018, 6369
Hydroxylation of Eleuthoside Synthetic Intermediates by P450BM3 (CYP102A1)
9) J O'Hanlon, X Ren, M Morris, L L Wong, J Robertson, Org. Biomol. Chem. 2017, 15, 8780
Hydroxylation of Anilides by Engineered Cytochrome P450BM3
10) L-D Syntrivanis, J Robertson, Eur. J. Org. Chem. 2017, 4916
Synthesis of (E)-4-Methylhexa-3,5-dienol and its Diels–Alder Reaction with Thioester Dienophiles: a Short Enantioselective Synthesis of Bicyclic Lactones
11) O Zhurakovskyi, S R Ellis, A L Thompson, J Robertson, Org. Lett. 2017, 19, 2174
Access to a Guanacastepene and Cortistatin-Related Skeleton via Ethynyl Lactone Ireland–Claisen Rearrangement and Transannular (4+3)-Cycloaddition of an Azatrimethylenemethane Diyl
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