Nicholas Kurti Junior Research Fellow

Position

Elizabeth MannNicholas Kurti Junior Research Fellow in Medicine, Brasenose College

Postdoctoral Fellow, Kennedy Institute

Qualifications

BSc, MSc, PhD

Academic Background and Previous Positions

I studied Medical Sciences at the University of Birmingham, undertaking a summer project funded by the Wellcome Trust which sparked my interest in medical research. Following this I moved to King’s College London where I completed a Masters in Immunology and carried out my PhD studies researching the roles of air pollution and vitamin D in asthma. I worked as a postdoctoral researcher at the Francis Crick Institute to complete a collaborative research project, and moved to the University of Oxford in October 2017 to study the roles of the immune system and microbiome in colon cancer.

As an enthusiastic and ambitious immunologist, I strive to alter patient care for the better, particularly focusing on individuals with treatment-refractory diseases. Beyond my research interests I am also passionate about disseminating my knowledge and experiences to others through public engagement activities and mentoring.

2017 on-going Post-doctoral researcher, The Kennedy Institute, University of Oxford

Nicholas Kurti Junior Research Fellow, Brasenose College, University of Oxford

Interactions between IL-22 and KRAS as a therapeutic target in colon cancer – Prof Fiona Powrie

2016 – Nov 2017 Post-doctoral researcher to complete article revisions, The Francis Crick Institute

PILA-C (certificate number BE2909)

The role of glycosylation in driving the synthesis of IL-17A and IL-10 by CD4+ T cells – Prof A O’Garra

2013 – 2016 PhD Studentship, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma

King’s College London and Imperial College London

Mechanisms underlying the immunoregulatory effects of corticosteroids, air pollution and vitamin D on the Th17 axis – Prof CM Hawrylowicz and Dr TT Hansel

2012 – 2013 MSc Immunology, King’s College London (Distinction, 85%)

Modulation of the adenosine and TGFβ pathways by vitamin D – Prof CM Hawrylowicz

2009 – 2012 BSc Medical Science, University of Birmingham (Honours Class I, 80%)

PI3K and altered neutrophil chemotaxis in the healthy aged – Prof JM Lord and Dr E Sapey

The role of Lyp phosphatase in neutrophil signalling – Dr SP Young

2002 – 2009 Upton-by-Chester High School – A-Level Chemistry A, Biology A and Mathematics with Statistics A (AS Level French); 10 GCSEs at A*/A; ABRSM Grade 8 flute

Undergraduate Teaching Areas

Immunology and oncology

Research Interests

Colorectal cancer is the third most common malignancy worldwide and is increasing in global incidence. It is particularly devastating for a subgroup of patients who respond poorly to current therapies. Therefore, to improve care for individuals with this devastating disease we need to better understand the underlying tumour biology and use this to influence clinical decision making.

My research uses a multi-pronged approach to better understand differences in the immune response and microbiome in poor prognosis colorectal cancer patients, and ultimately ways in which we can harvest this knowledge therapeutically. This involves 1) analysing gene expression data sets, 2) growing mini-tumours (organoids) in the lab, 3) microscopic imaging of candidate molecules and 4) an early phase clinical trial in poor-prognosis colon cancer.

Publications

McCuaig S, Barras D, Mann EH, Friedrich M, Bullers S, Janney A, Garner L, Swamy M, Delorenzi M, Tejpar S, Maughan T, West N, Powrie F. ‘The interleukin 22 pathway interacts with mutant KRAS to promote poor prognosis in colon cancer’. Under review.

Mann EH, Gabrysova L, Pfeffer PE, O’Garra A, Hawrylowicz CM. ‘High dose IL-2 skews a glucocorticoid-driven IL-17A+IL-10+ memory CD4+ T cell response towards a single IL-10-producing phenotype’. Journal of Immunology. 2019; 1;202(3):684-693.

Recaldin T, Hobson PS, Mann EH, Ramadani D, Cousins D, Lavender P, Fear DF. ‘miR-29b directly targets activation-induced cytidine deaminase in human B cells and can limit its inappropriate expression in naïve B cells’. Mol Immunol. 2018; 101:419-428.

Mann EH, Gabrysova L, Pfeffer PE, O’Garra A, Hawrylowicz CM. ‘High dose IL-2 skews a glucocorticoid-driven IL-17A+IL-10+ memory CD4+ T cell respiknse towards a single IL-10-producing phenotype’. Journal of Immunology; under minor revisions.

Gabrysova L, Mann EH, Bradley L, MacRae JI, Wicher C, Hawrylowicz CM, Anastasious D, O’Garra A. Glycosylation-dependent modulation of the IL-2 signalling axis determines Th17 differentiation and IL-10 production. Bio-Archive. 2018.

Pfeffer PE, Haw L, Mann EH, Che YH, Ho TZ, Cousins DJ, Corrigan C, Kelly FJ, Mudway IS, Hawrylowicz CM. ‘Effects of vitamin D on inflammatory and oxidative response of human bronchial epithelial cells exposed to particulate matter’. PLOS One; under minor revisions.

Thwaites R, Gunwardana N, Brioch V, Mann EH, Ahnstom J, Campbell G, Lindsley S, Singh N, Tunstall T, Lane D, Openshaw P, Hawrylowicz C, Hansel TT. ‘Biphasic activation of complemen and fibrinolysis during the human nasal allergic response’. JACI. 2018; 141(5): 1892-1895.e6.

Pfeffer PE, Tzer R H, Mann EH, Kelly FJ, Sehlstedt M, Pourazar J, Dove RE, Sandstrom T, Mudway I, Hawrylowicz CM. ‘Urban particulate matter stimulation of human dendritic cells enhances priming of naïve CD8 T lymphocytes’. Immunology. 2017; 153(4): 502-512.

Mann EH, Tzer-Ren H, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ and Hawrylowicz CM. ‘Vitamin D counteracts an IL-23-dependent IL-17A+IFN𝛾+ response driven by urban particulate matter’. Am J Respir Cell Mol Biol. 2017; 57(3):355-366. – chosen for editorial

Matthews NC, Pfeffer PE, Mann EH, Kelly FJ, Corrigan CJ, Hawrylowicz CM and Lee TH. ‘Urban Particulate Matter-activated human dendritic cells induce expansion of potent inflammatory Th1, Th2 and Th17 effector cells’. Am J Respir Cell Mol Biol. 2016; 54(2):250-62.

Mann EH, Chambers ES, Chen YH, Richards DF and Hawrylowicz CM. ‘1α,25-dihydroxyvitaminD3 acts via TGFβ to upregulate expression of immunosuppressive CD73 on human CD4+Foxp3-negative T cells’. Immunology. 2015; 146(3):423-31.

Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G and Hawrylowicz CM. ‘1alpha,25-dihydroxyvitaminD3 in combination with TGFβ increases the frequency of Foxp3+ Tregs through preferential expansion and usage of IL-2’. Immunology. 2014; 143(1):52-60.

Sapey E, Greenwood H, Walton G, Mann EH, Love A, Aaronson N, Insall RH, Stockley RA and Lord JM. ‘Phosphoinositide 3 kinase inhibition restores neutrophil accuracy in the elderly: towards targeted treatments for immunesenescence’. Blood. 2014; 123(2):239-48.

Other

Awards and prizes

2018 Nicholas Kurti Junior Research Fellowship (3 years)

2016 FCE Fellowship to attend FOCIS annual meeting

2016 MRC Supplement Grant to fund BD Biosciences FACS Aria III training

2016 EACCI Winter School Poster Prize

2015 KCL Graduate Conference Grant and BSI Travel Award

2015 ImmunoTools-Award

2014 BSI travel award and congress Poster Prize

2013 MSc Immunology ‘Best Overall Performance’, King’s College London

2013 BSI Bursary

2012 Arthur Thompson Prize for the ‘Most Able Final Year Student’, University of Birmingham

2012 Universitas 21 Undergraduate Research Conference ‘Best Oral Presentation’

2012 Japanese Ministry of Education Travel Scholarship

2011 Selected as personal mentee of Sir Liam Donaldson (Chief Medical Officer 1998-2010)

2011 Wellcome Trust Biomedical Vacation Scholarship

2010 Garland Science Award for ‘Best Performing 1st Year BMedSc’, University of Birmingham

E-mail

[email protected]

 

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