Ian Gibbs-Seymour, a Nicholas Kurti Junior Research Fellow at Brasenose College and postdoctoral researcher in Ivan Ahel’s group at the Sir William Dunn School of Pathology, has been awarded a Marie Curie Fellowship in the latest funding round.
His project, titled: ‘Regulation of ADP-ribosylation signalling in the DNA damage response’, aims to reveal how ADP-ribosylation signalling contributes to genome stability and disease prevention.
Ian said: “The project will allow me to build on some exciting preliminary data and explore the physiological relevance of how a post-translational modification, called ADP-ribosylation, contributes to the stability of DNA in our cells. Inability to repair and faithfully restore the genetic material upon damage gives rise to a range of diseases, including various cancers. We hope that the work described in this proposal will provide novel mechanistic insights into ADP-ribosylation signalling and further our understanding of its role in genome maintenance pathways.”
The Fellowship is named in honour of Marie Curie, the chemist and physicist who won two nobel prizes.
Visit the Ivan Ahel group pages for further information about the group's research and read more about Biochemistry at Brasenose College.