Brasenose College, Oxford - Dr Jeremy Taylor
Dr Jeremy Taylor
Name and Title
Dr Jeremy Taylor
Qualifications
BSc (Bristol), MA (Oxford), PhD (London)
Academic Positions
Lecturer in Human Anatomy, Brasenose College
Academic Background and Previous Positions
University Lecturer and Tutorial Fellow, Pembroke College, University of Oxford
Wellcome Trust Vision Research Fellow, University of Oxford
Post Doctoral Research Worker, University of Oxford
Post Doctoral Research Fellow University of Edinburgh
PhD NIMR Mill Hill London
Undergraduate Teaching Areas
Embryology
Neuroscience especially CNS development and regeneration
Graduate Teaching Areas
Neuroscience especially CNS development and regeneration
Research Interests
How do nerve fibres know where to grow and why do they fail to regrow when the nervous system is damaged?
We are interested in the development of the vertebrate central nervous system, particularly the visual and corticospinal systems, and specifically at points of axon decussation which are complex decision regions.
The regeneration of axons within the adult CNS is characteristically very poor, especially for projection neurons. However, we have shown that in RGC axons will re-navigate their appropriate pathways and re-establish connectivity during a defined time window of late development. At this time the neurons are still capable of transcribing their original growth related genes, and are in a CNS environment that is neither inhibitory, nor has lost the guidance cues essential for correct navigation. We are currently exploring the limits on this response using both neurotrophins and Glial cell derived factors to extend the regenerative period.
Publications
Ma CH and Taylor JSH (2009). Trophic Responsiveness of Purified Postnatal and Adult Rat Retinal Ganglion Cells. Cell Tissue Research In Press
Ma, C.H., Bampton E.T.W., Evans, M.J., Taylor J.S.H. (2009). Synergistic effects of osteonectin and BDNF on axotomized retinal ganglion cells neurite outgrowth via MAPK-Erk1/2 pathways. Neuroscience In Press
Ma CH, Palmer A, Taylor JSH. (2009). Synergistic effects of osteonectin and NGF in promoting survival and neurite outgrowth of superior cervical ganglion neurons. Brain Res.1289:1-13.
Wang J, Chan CK, Taylor JSH, Chan SO. (2008). The growth-inhibitory protein Nogo is involved in midline routing of axons in the mouse optic chiasm. J Neurosci Res. 86(12):2581-90.
Wang J, Chan CK, Taylor JSH, Chan SO. (2008) Localization of Nogo and its receptor in the optic pathway of mouse embryos. J Neurosci Res. 86(8):1721-33.
de Melo Reis RA, Cabral-da-Silva MC, de Mello FG, Taylor JSH.(2008). Müller glia factors induce survival and neuritogenesis of peripheral and central neurons. Brain Res. 1205:1-11.
Bampton, ETW, Ma, E, Tolkovsky AM and Taylor JSH (2005). Identification of Osteonectin as a Schwann Cell Secreted Molecule Mediating Neuronal Regeneration of Damaged Neurons. Eur. J Neurosci. 21:2611-23.
Bampton, ETW and Taylor JSH (2005). Effects of Schwann cell secreted factors on PC12 cell neuritogenesis and survival. J Neurobiol. 63:29-48.
Other
Chairman of the FHS Biomedical Science Honours School
Chairman of the Organising Committee MSc and Wellcome Trust four year programme in Neuroscience
Departmental Director of Graduate Studies
Links
http://www.dpag.ox.ac.uk/research/neuro/jeremy_taylor
Admissions Links